Amygdala Resting Connectivity Mediates Association Between Maternal Aggression and Adolescent Major Depression: A 7-Year Longitudinal Study

BL Callaghan; O Dandash; JG Simmons; O Schwartz; ML Byrne; L Sheeber; NB Allen; S Whittle

Journal article

Amygdala Resting Connectivity Mediates Association Between Maternal Aggression and Adolescent Major Depression: A 7-Year Longitudinal Study

BL Callaghan, O Dandash, JG Simmons, O Schwartz, ML Byrne, L Sheeber, NB Allen, S Whittle

Journal of the American Academy of Child and Adolescent Psychiatry | ELSEVIER SCIENCE INC | Published : 2017

DOI: 10.1016/j.jaac.2017.09.415

Abstract

Objective The parent–adolescent relationship is an important predictor of adolescent mental health, especially depressive disorders. This relationship is constructed in the context of maturing emotion neurobiology and could help shape such neurobiology in ways that are important for current and future mental health. Amygdala resting-state functional networks have been linked to depression, but whether such resting connectivity is associated with parent affective behaviors or acts as a salient mediator between parenting and risk for depressive disorder is unknown. Method In the present study of 128 individuals, a 7-year longitudinal design was used to examine how observed maternal aggressive ..

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University of Melbourne Researchers

Orwa Dandash Author

Julian Simmons Author

Orli Schwartz Author

Nick Allen Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia, program grant 350241), and the Australian Research Council (Discovery Grants DP0878136 and DP1092637). Dr Callaghan was supported by an NHMRC Early Career Fellowship (1091571). Dr. Whittle was supported by an NHMRC Career Development Fellowship (1007716).